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Synthesis and Antiplatelet Aggregation Activities in Vitro …

And in which some compounds exhibited higher antiplatelet aggregation activities than picotamide []. After 2005, in continuation of our interest on the synthesis of related compounds N,N''-disubstitutedphenyl-4-methoxyl-benzene-1,3-disulfonamidesseries of series 2 ( Figure 1 ) [ 6 - 8 ], it is based on that benzene-1,3-disulfonamide is the isostere of isophthalamide.

In Vitro Antiplatelet Aggregation Activity of Aqueous and …

In this study, antiplatelet aggregation activities of aqueous and alcoholic extracts of AILE were performed at the concentration of 200, 400 and 800 µg/ml respectively. The effect of extracts at different concentrations were measured and compared with the standard drug

Molecules | Free Full-Text | Anti-Platelet Aggregation and …

Coffee is rich in caffeine (CF), chlorogenic acid (CGA) and phenolics. Differing types of coffee beverages and brewing procedures may result in differences in total phenolic contents (TPC) and biological activities. Inflammation and increases of platelet activation and aggregation can lead to thrombosis. We focused on determining the chemical composition, antioxidant activity and inhibitory ...

Synthesis and Evaluation of in vitro Antiplatelet …

Title:Synthesis and Evaluation of in vitro Antiplatelet Aggregation Activities of 2-Methoxy-5-Aminobenzamides VOLUME: 16 ISSUE: 9 Author(s):Lili Liu, Xiujie Liu*, Guangling Chen and Kai Qiu Affiliation:School of Chemistry and Chemical Engineering, Tianjin University of Technology, 300384, Tianjin, School of Chemistry and Chemical Engineering, Tianjin University of Technology, 300384, …

(PDF) ARTICLE Evaluation of a multifunctional …

ARTICLE Evaluation of a multifunctional staphylokinase variant with thrombin inhibition and antiplatelet aggregation activities produced from salt-inducible E. coli GJ1158

Synthesis and the Evaluations in vitro Antiplatelet …

Synthesis and the Evaluations in vitro Antiplatelet Aggregation Activities of 4-Ethoxyisophthalamides. Liu XJ(1), Shi TE, Wang X, Wei TT, Meng X. Author information: (1)College of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China. [email protected] .

New Copper Compounds with Antiplatelet Aggregation …

EPR spectra suggest that the geometry of the complexes is similar to that observed in the solid state by X-ray crystallography. Compound (C2) exhibited the strongest antiplatelet aggregation activity.

Synthesis and in vitro activities on anti-platelet …

Abstract Cardiovascular diseases are the most frequent cause of morbidity and mortality worldwide. In order to discover novel compounds with anti-platelet aggregation activities, a series of novel 4-methoxy-1,3-phthalamidesamides (1a–1i) and a series of novel 4-methoxy-1,3-benzenedisulfon-amides (2a–2i) were synthesized and their anti-platelet aggregation activities were evaluated by the ...

New Copper Compounds with Antiplatelet Aggregation …

New Copper Compounds with Antiplatelet Aggregation Activity

Anti-coagulation and Anti-platelet Aggregation Activities of …

Anti-coagulation and Anti-platelet Aggregation Activities of Black Ginger (Kaempferia parviflora) Man-Hyo Lee1, Hwa-Jung Sung2, Chong Suk Kwon2 and Ho-Yong Sohn2* 1Gyeongbuk Institute For Bio-Industry, Andong 36728, Korea 2Department of Food and Nutrition, Andong National University, A …

Synthesis and in vitro anti-platelet aggregation activities of 2 …

aggregation activities were higher when the electron-withdrawing chloro groups were introduced into ortho position or the electron-donating methyl groups were introduced into the para position. For AA-induced platelet aggregation, compounds 1b (IC 50: 0.23µM 50 ...

Anti-inflammatory, Antiplatelet Aggregation, and Antiangiogenesis Polyketides …

Anti-inflammatory, Antiplatelet Aggregation, and Antiangiogenesis Polyketides from Epicoccum sorghinum: Toward an Understating of Its Biological Activities and Potential Applications Chi-Ying Li,⊥⊥ Ching-Chia Chang,⊥⊥ Yi-Hong Tsai, Mohamed El-Shazly, Chin-Chung Wu, ...

Article Anti-Platelet Aggregation and Anti-Cyclooxygenase Activities …

Article Anti-Platelet Aggregation and Anti-Cyclooxygenase Activities for a Range of Coffee Extracts (Coffea arabica) Nuntouchaporn Hutachok1, Pongsak Angkasith2, Chaiwat Chumpun2, Suthat Fucharoen3, Ian J. Mackie4, John B. Porter5 and Somdet Srichairatanakool1* ...

New Copper Compounds with Antiplatelet Aggregation …

Compound (C2) exhibited the strongest antiplatelet aggregation activity. Conclusion: Schiff base copper(II) complexes, which are attracting increasing interest, could represent a new approach to treat thrombosis by blocking the activity of PolyP with a potential anticoagulant activity and, most importantly, demonstrating no adverse bleeding events.

Antiplatelet drug

An antiplatelet drug (antiaggregant), also known as a platelet agglutination inhibitor or platelet aggregation inhibitor, is a member of a class of pharmaceuticals that decrease platelet aggregation and inhibit thrombus formation. They are effective in the arterial …

Synthesis of phthalide derivatives and evaluation on their …

(2020). Synthesis of phthalide derivatives and evaluation on their antiplatelet aggregation and antioxidant activities. Journal of Asian Natural Products Research: Vol. 22, No. 12, pp. 1176-1187.

Antiplatelet and Antioxidant Activities of Tomato

These fractions were screened for the presence of activities against arachidonic acid (AA) metabolism and agonist-induced human platelet aggregation. These fractions were also investigated for their potential to enhance the activities of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx).

Antiplatelet and Antioxidant Activities of Tomato

Antiplatelet and Antioxidant Activities of Tomato Abdul Waheed Khan 1,, Kashif Iqbal 1, Sagheer Ahmed 2,, Saima Gul 3, Arif-ullah Khan 4, Muhammad Usman 1 and Hafsa Bibi 5 1 Department of Pharmacy, University of Lahore, Islamabad, Pakistan 2 Shifa College of Pharmaceutical Sciences, Shifa Tameer-E-Millat University, Islamabad, Pakistan ...

Chemical constituents from heartwoods of Caesalpinia …

The in vitro antiplatelet aggregation activities were evaluated using mouse platelet induced by AYPGKF-NH 2, a gold agonist of protease-activated receptor 4 (PAR4). Results Two new phenols, methyl 2-(4,4′,5′-trihydroxy-2′-(methoxymethyl) biphenyl-2-yloxy) acetate ( 1 ) and 1′-methylcaesalpin J ( 2 ), together with 24 known compounds ( 3 – 26 ), were isolated from the heartwoods of C ...

Synthesis and Evaluation of in vitro Antiplatelet Aggregatio

A total of twenty new compounds 1a-1t have been synthesized and evaluated for their antiplatelet aggregation activities in vitro. Methods: In the structural design of target compounds 1a-1t, the betrixaban was retained group characteristics and the picotamide was …

Synthesis and in vitro anti-platelet aggregation activities of 2 …

In vitro anti-platelet aggregation activities of target compounds were assessed on rabbit platelet by turbidimetric test.[27] ADP, AA, and collagen were employed as inducers of platelet aggregation. Picota-mide and aspirin were used as positive controls. Those 50

Alkaloids from Houttuynia cordata and Their Antiplatelet …

 · Antiplatelet aggregation test indicated significant inhibitory activities of compounds 1, 2, 4-7, 9 induced by ADP and 1, 2, 4, 7 induced by thrombin. CONCLUSION: Compounds 2, 6, 7, 9 were isolated from the genus Houttuynia for the first time. Compounds 1, 2, 4, 7 showed significant inhibitory effects on both ADP-induced and thrombin-induced ...

Synthesis and Antiplatelet Aggregation Activity …

 · A series of novel 2-aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine derivatives have been synthesized and their antiplatelet aggregation activities were assessed against ADP and arachidonic acid-induced platelet aggregation in human plasma using light transmission aggregometry. Among the tested derivatives, compounds Ia, Ib, IB and II16 exhibited the highest antiplatelet aggregation ...

Pharma Sci-Synthesis and Antiplatelet Aggregation …

And in which some compounds exhibited higher antiplatelet aggregation activities than picotamide. After 2005, in continuation of our interest on the synthesis of related compounds N,N''-disubstitutedphenyl-4-methoxyl-benzene-1,3-disulfonamidesseries of series 2 ( Figure 1 ), it is based on that benzene-1,3-disulfonamide is the isostere of isophthalamide.

Anti-Platelet Aggregation and Anti-Cyclooxygenase …

Coffee is rich in caffeine (CF), chlorogenic acid (CGA) and phenolics. Differing types of coffee beverages and brewing procedures may result in differences in total phenolic contents (TPC) and biological activities. Inflammation and increases of platelet activation and aggregation can lead to thrombosis. We focused on determining the chemical composition, antioxidant activity and inhibitory ...

In Vitro Antiplatelet Aggregation Activity of Centella asiatica (L.) …

Agatha et al. / In Vitro Antiplatelet… IJPCR, April 2016, Volume 8, Issue 4 Page 282 Figure 2: Curve of CEE (pCEE and npCEE) activity on platelet aggregation (%). Preparation of platelet-rich plasma (PRP) and platelet-poor plasma (PPP) Rats (Sprague dawley

Antiplatelet properties of natural products

This article provides a brief overview of the atherothrombotic process to further provide an up-to-date review of the antiplatelet properties exerted by natural products and/or food-derived bioactive constituents - including ω-3 PUFA, olive oil, garlic and onions, tomatoes, mushrooms, polyphenol-rich beverages, and flavonol-rich cocoa - as well as ...

Anti-platelet aggregation activities of different fractions in …

 · MATERIALS AND METHODS: Nephelometery was applied to evaluate anti-platelet aggregation activity of multi-components of A. venetum. Systematic separation components were characterized by HPLC analysis method, and in vitro screening active components by anti-platelet aggregation study.

Chemical Constituents and Anti-platelet Aggregation Activity from …

root exerted anti-platelet aggregation activity in prelimi-nary screening and subsequent investigation, which led to the isolation of 32 known compounds. In this paper, we report the isolation, the anti-platelet aggregation activities of these isolates, and the